Probabilistic assessment of Net Transfer Capacity considering forecast uncertainties

In transmission system planning, researchers propose methods to assess the effect of uncertainties of power system operating condition due to forecasting errors of intermittent generation and loads. In particular probabilistic power flow methods are used to calculate the probability distributions of the voltages and the branch currents, starting from the distributions of power injections/absorptions. These uncertainties play a key role in the operational planning of power systems, as certain configurations of load and intermittent generation can cause security problems. This paper aims to propose a probabilistic methodology to assess Net Transfer Capacity (NTC) among network areas, which quantifies forecast error uncertainties by applying the Point Estimate Method (PEM) combined with Third Order Polynomial Normal (TPN) Transformation. This approach is compared with a conventional NTC assessment technique and has been tested on an IEEE test system

¿Cuáles son los determinantes de la demanda de seguros agrícolas en Italia?

[EN] This paper is aimed to highlight the factor which mainly affect the crop insurance demand in Italy. By using Farm Accountancy Data Network (FADN), we carried out a logit model to implement the econometrics analysis for this scope. The higher concentration in high size farmers of the policy, stimulate a reflection on the public role in support of risk management in agriculture, reconsidering the “social” nature of this kind of support, at least if only direct versus crop insurance.[ES] El objetivo de este trabajo es identificar los factores que influyen principalmente a la hora de suscribir una póliza de seguro sobre los cultivos en Italia. Utilizando los datos de la muestra de la Red Contable Agraria Italiana (RICA) y un modelo logit para el análisis econométrico. La elevada concentración de las pólizas, sobre todo de las grandes empresas, invita a reflexionar sobre el papel de la intervención pública en la gestión del riesgo en la agricultura y a reconsiderar el valor “social” de la misma, por lo menos en su forma actual.Capitanio, F.; Adinolfi, F.; Di Pasquale, J.; Contò, F. (2013). Which factors would affect crop insurance demand in Italy?. Economía Agraria y Recursos Naturales - Agricultural and Resource Economics. 13(1):5-25. https://doi.org/10.7201/earn.2013.01.01SWORD52513

BRIO: a web server for RNA sequence and structure motif scan

The interaction between RNA and RNA-binding proteins (RBPs) has a key role in the regulation of gene expression, in RNA stability, and in many other biological processes. RBPs accomplish these functions by binding target RNA molecules through specific sequence and structure motifs. The identification of these binding motifs is therefore fundamental to improve our knowledge of the cellular processes and how they are regulated. Here, we present BRIO (BEAM RNA Interaction mOtifs), a new web server designed for the identification of sequence and structure RNA-binding motifs in one or more RNA molecules of interest. BRIO enables the user to scan over 2508 sequence motifs and 2296 secondary structure motifs identified in Homo sapiens and Mus musculus, in three different types of experiments (PAR-CLIP, eCLIP, HITS). The motifs are associated with the binding of 186 RBPs and 69 protein domains. The web server is freely available at http://brio.bio.uniroma2.it

Coping with Risks in the Mediterranean Countries? Let the experts explain

A decade of major political, institutional, economic and societal changes is challenging the Mediterranean Area: in a more and more globalized Europe the primary sectors of Mediterranean Partner Countries (MPCs) are largely influenced by recent trends. The resulting exposure of Mediterranean Countries’ agriculture to risks has called great attention on risk management strategies and public intervention. We explore their role in three selected Countries, namely Syria, Tunisia and Turkey with a view to a unified policy framework. The analysis is conducted through a field activity that has allowed to understand the key issues. The experts’ opinions draw a clear picture of retrospect and prospects and stimulate a comparative analysis that widens the current knowledge of risk management in the Mediterranean Countries

Monitoring the Microseismicity through a Dense Seismic Array and a Similarity Search Detection Technique: Application to the Seismic Monitoring of Collalto Gas-Storage, North Italy

Seismic monitoring in areas where induced earthquakes could occur is a challenging topic for seismologists due to the generally very low signal to noise ratio. Therefore, the seismological community is devoting several efforts to the development of high-quality networks around the areas where fluid injection and storage and geothermal activities take place, also following the national induced seismicity monitoring guidelines. The use of advanced data mining strategies, such as template matching filters, auto-similarity search, and deep-learning approaches, has recently further fostered such monitoring, enhancing the seismic catalogs and lowering the magnitude of completeness of these areas. In this framework, we carried out an experiment where a small-aperture seismic array was installed within the dense seismic network used for monitoring the gas reservoir of Collalto, in North Italy. The continuous velocimetric data, acquired for 25 days, were analysed through the application of the optimized auto-similarity search technique FAST. The array was conceived as a cost-effective network, aimed at integrating, right above the gas storage site, the permanent high-resolution Collalto Seismic Network. The analysis allowed to detect micro-events down to magnitude Ml = −0.4 within a distance of ~15 km from the array. Our results confirmed that the system based on the array installation and the FAST data analysis might contribute to lowering the magnitude of completeness around the site of about 0.7 units

Circulating miRNA-195-5p and -451a in Patients with Acute Hemorrhagic Stroke in Emergency Department

(1) Background: In our previous study, acute ischemic stroke (AIS) patients showed increased levels of circulating miRNAs (-195-5p and -451a) involved in vascular endothelial growth factor A (VEGF-A) regulation. Here, we evaluated, for the first time, both circulating miRNAs in acute intracerebral hemorrhagic (ICH) patients. (2) Methods: Circulating miRNAs and serum VEGF-A were assessed by real-time PCR and ELISA in 20 acute ICH, 21 AIS patients, and 21 controls. These were evaluated at hospital admission (T0) and after 96 h (T96) from admission. (3) Results: At T0, circulating miRNAs were five-times up-regulated in AIS patients, tending to decrease at T96. By contrast, in the acute ICH group, circulating miRNAs were significantly increased at both T0 and T96. Moreover, a significant decrease was observed in serum VEGF-A levels at T0 in AIS patients, tending to increase at T96. Conversely, in acute ICH patients, the levels of VEGF-A were significantly decreased at both T0 and T96. (4) Conclusions: The absence of a reduction in circulating miRNAs (195-5p and -451a), reported in acute ICH subjects after 96 h from hospital admission, together with the absence of increment of serum VEGF-A, may represent useful biomarkers indicating the severe brain damage status that characterizes acute ICH patients

Insulin-resistance HCV infection-related affects vascular stiffness in normotensives

Background and Aims. Arterial stiffness evaluated as pulse wave velocity, is an early marker of vascular damage and an independent predictor for cardiovascular events. We investigated if the insulin resistance/hyperinsulinemia chronic hepatitis C virus infection-related could influence arterial stiffness. Methods. We enrolled 260 outpatients matched for age, body mass index, gender, ethnicity: 52 with never-treated uncomplicated chronic hepatitis C virus infection (HCV+), 104 never-treated hypertensives (HT) and 104 healthy subjects (NT). Pulse wave velocity was evaluated by a validated system employing high-fidelity applanation tonometry. We also measured: fasting plasma glucose and insulin, total, LDL- and HDL-cholesterol, triglyceride, creatinine, e-GFR-EPI, HOMA, quantitative HCV-RNA. Results. HCV+ patients with respect to NT had an increased pulse wave velocity (7.9 ± 2.1 vs 6.4 ± 2.1 m/s; P < 0.0001), similar to that observed in HT group (8.8 ± 3.2 m/s). HCV+ patients, in comparison with NT, had higher triglyceride, creatinine, fasting insulin and HOMA (3.2 ± 1.3 vs 2.5 ± 1.0; P < 0.0001). At linear regression analysis, the correlation between pulse wave velocity and HOMA was similar in HT (r = 0.380, P < 0.0001) and HCV+ (r = 0.369, P = 0.004) groups. At multiple regression analysis, HOMA resulted the major determinant of pulse wave velocity in all groups, explaining respectively 11.8%, 14.4% and 13.6% of its variation in NT, HT and HCV+. At correlational analysis hepatitis C virus-RNA and HOMA demonstrated a strong and linear relationship between them, explaining the 72.4% of their variation (P = 0.022). Conclusions. We demonstrated a significant and direct correlation between HOMA and pulse wave velocity in HCV+ patients, similar to that observed in hypertensive

Denatonium as a Bitter Taste Receptor Agonist Modifies Transcriptomic Profile and Functions of Acute Myeloid Leukemia Cells

The contribution of cell-extrinsic factors in Acute Myeloid Leukemia (AML) generation and persistence has gained interest. Bitter taste receptors (TAS2Rs) are G protein-coupled receptors known for their primary role as a central warning signal to induce aversion toward noxious or harmful substances. Nevertheless, the increasing amount of evidence about their extra-oral localization has suggested a wider function in sensing microenvironment, also in cancer settings. In this study, we found that AML cells express functional TAS2Rs. We also highlighted a significant association between the modulation of some TAS2Rs and the poor-prognosis AML groups, i.e., TP53- and TET2-mutated, supporting a potential role of TAS2Rs in AML cell biology. Gene expression profile analysis showed that TAS2R activation with the prototypical agonist, denatonium benzoate, significantly modulated a number of genes involved in relevant AML cellular processes. Functional assay substantiated molecular data and indicated that denatonium reduced AML cell proliferation by inducing cell cycle arrest in G0/G1 phase or induced apoptosis via caspase cascade activation. Moreover, denatonium exposure impaired AML cell motility and migratory capacity, and inhibited cellular respiration by decreasing glucose uptake and oxidative phosphorylation. In conclusion, our results in AML cells expand the observation of cancer TAS2R expression to the setting of hematological neoplasms and shed light on a role of TAS2Rs in the extrinsic regulation of leukemia cell functions

Extracellular ATP is increased by release of ATP-loaded microparticles triggered by nutrient deprivation

Rationale: Caloric restriction improves the efficacy of anti-cancer therapy. This effect is largely dependent on the increase of the extracellular ATP concentration in the tumor microenvironment (TME). Pathways for ATP release triggered by nutrient deprivation are largely unknown. Methods: The extracellular ATP (eATP) concentration was in vivo measured in the tumor microenvironment of B16F10-inoculated C57Bl/6 mice with the pmeLuc probe. Alternatively, the pmeLuc-TG-mouse was used. Caloric restriction was in vivo induced with hydroxycitrate (HC). B16F10 melanoma cells or CT26 colon carcinoma cells were in vitro exposed to serum starvation to mimic nutrient deprivation. Energy metabolism was monitored by Seahorse. Microparticle release was measured by ultracentrifugation and by Nanosight. Results: Nutrient deprivation increases eATP release despite the dramatic inhibition of intracellular energy synthesis. Under these conditions oxidative phosphorylation was dramatically impaired, mitochondria fragmented and glycolysis and lactic acid release were enhanced. Nutrient deprivation stimulated a P2X7-dependent release of ATP-loaded, mitochondria-containing, microparticles as well as of naked mitochondria. Conclusions: Nutrient deprivation promotes a striking accumulation of eATP paralleled by a large release of ATP-laden microparticles and of naked mitochondria. This is likely to be a main mechanism driving the accumulation of eATP into the TME

A Highly Integrated Navigation Unit for On-Orbit Servicing Missions

VINAG (VISION/INS integrated Navigation Assisted by GNSS) is a highly integrated multisensor navigation unit, particularly conceived for On-Orbit Servicing missions. The system is designed to provide all-in-one, on-board real time autonomous absolute navigation as well as pose determination of an uncooperative known object orbiting in LEO (Low Earth Orbit), GEO (GEosynchronous Orbits) and possibly in HEO (Highly Earth Orbit). The system VINAG is under development by a team of Italian companies and universities, co-financed by the Italian Space Agency. Thanks to a tight optimized integration of its subsystems, VINAG is characterized by a low power and mass total budgets and therefore it is suitable for small and very small satellites. In order to provide both 1) absolute orbit and attitude determination and 2) vision-based pose determination, the unit integrates three metrology systems: a Cameras Subsystem (a monocular camera and a Star sensor), an Inertial Measurement Unit (IMU) and a GNSS (Global Navigation Satellite System) receiver. In this paper, we introduce the complete system architecture, the adopted algorithms and then the adopted hardware design solutions. In addition, we describe preliminary numerical simulation results obtained for different orbits from LEO to GEO carried out for the validation phase of VINAG